Sodium Oxybate for Excessive Daytime Sleepiness in Narcolepsy-Cataplexy
نویسندگان
چکیده
منابع مشابه
Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience.
Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 positive, 17/17 with low/absent cerebrospinal fluid hypocretin) in whom SO was prescribed. After 26 ± 13 months, 13/18 patients were still on SO at a mean dosage ...
متن کاملSodium oxybate for excessive daytime sleepiness in Parkinson disease: an open-label polysomnographic study.
BACKGROUND Many patients with Parkinson disease (PD) have excessive daytime sleepiness and numerous nocturnal sleep abnormalities. OBJECTIVE To determine the safety and efficacy of the controlled drug sodium oxybate in a multicenter, open-label, polysomnographic study in subjects with PD and sleep disorders. Design, Setting, and Patients Inclusion required an Epworth Sleepiness Scale (ESS) sc...
متن کاملNarcolepsy with Cataplexy Is Characterized by Excessive Daytime Sleepiness, Cataplexy (a Sudden Bilateral Loss of Voluntary Muscle
NARCOLEPSY WITH CATAPLEXY IS CHARACTERIZED BY EXCESSIVE DAYTIME SLEEPINESS, CATAPLEXY (A SUDDEN BILATERAL LOSS OF VOLUNTARY MUSCLE tone provoked by emotions) and, facultatively, by other rapid eye movement (REM) sleep phenomena such as sleep paralysis and hallucinations (narcoleptic tetrad). Patients with narcolepsy with cataplexy have normal amounts of sleep over 24 hours, 1-3 but their day-ni...
متن کاملSodium Oxybate for Narcolepsy
1a. Is sodium oxybate safe and clinically effective in the reduction in number and intensity of cataplexy attack, excessive day-time sleepiness (diurnal naps), nocturnal awakenings, terrifying dream experiences, insomnia, hypnagogic hallucinations, sleep paralysis, and improvement in quality of life in adult patients with narcolepsy and cataplexy compared to no intervention, combined treatment ...
متن کاملPharmacotherapy for excessive daytime sleepiness.
Excessive daytime sleepiness (EDS) has recognized detrimental consequences such as road traffic accidents, impaired psychological functioning and reduced work performance. EDS can result from multiple causes such as sleep deprivation, sleep fragmentation, neurological, psychiatric and circadian rhythm disorders. Treating the underlying cause of EDS remains the mainstay of therapy but in those w...
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ژورنال
عنوان ژورنال: Sleep
سال: 2004
ISSN: 1550-9109,0161-8105
DOI: 10.1093/sleep/27.7.1242